Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice.
نویسندگان
چکیده
The Mga protein in B514Sm, a Streptococcus pyogenes strain isolated as a mouse pathogen, contains amino acid substitutions at conserved sites that render the protein defective. Replacement of mga50 with the functional homolog mga4.1 restored full expression of Mga-regulated proteins. Restoration of Mga function did not affect fibrinogen binding, nor did it affect virulence in several mouse models of group A streptococcus infection.
منابع مشابه
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ورودعنوان ژورنال:
- Infection and immunity
دوره 69 2 شماره
صفحات -
تاریخ انتشار 2001